Assay Detail
Functional
CHEMBL5133383
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Antiproliferative activity against human H460 cells by CCK8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.17 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27323 | — | — | 1 | 6.41 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.52 |
| CHEMBL5189650 | — | — | 1 | 5.39 |
| CHEMBL5191447 | — | — | 1 | 5.27 |
| CHEMBL5176870 | — | — | 1 | 5.20 |
| CHEMBL204860 | MATRINE | — | 1 | 5.15 |
| CHEMBL5183570 | — | — | 1 | 5.14 |
| CHEMBL5198782 | — | — | 1 | 5.14 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.12 |
| CHEMBL5189301 | — | — | 1 | 5.09 |
| CHEMBL5193168 | — | — | 1 | 5.07 |
| CHEMBL5187734 | — | — | 1 | 5.03 |
| CHEMBL5191239 | — | — | 1 | 5.00 |
| CHEMBL5203614 | — | — | 1 | 4.82 |
| CHEMBL5175502 | — | — | 1 | 4.69 |
| CHEMBL5200525 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27323 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5189650 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL5191447 | — | IC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL5176870 | — | IC50 | = | 6310.0 | nM | 5.20 |
| CHEMBL204860 | MATRINE | IC50 | = | 7030.0 | nM | 5.15 |
| CHEMBL5183570 | — | IC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL5198782 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 7570.0 | nM | 5.12 |
| CHEMBL5189301 | — | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL5193168 | — | IC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL5187734 | — | IC50 | = | 9270.0 | nM | 5.03 |
| CHEMBL5191239 | — | IC50 | = | 10040.0 | nM | 5.00 |
| CHEMBL5203614 | — | IC50 | = | 15010.0 | nM | 4.82 |
| CHEMBL5175502 | — | IC50 | = | 20380.0 | nM | 4.69 |
| CHEMBL5200525 | — | IC50 | = | 21320.0 | nM | 4.67 |