Assay Detail
Functional
CHEMBL5133441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity in primary neocortical neuron (unknown origin) assessed as inhibition of 4-AP-induced spontaneous calcium channel oscillation frequency measured after 15 min by Fluo-4AM dye based fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Not specified |
| Cell Type | Primary neocortical neuron |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Cadinane Sesquiterpenoids and Their Glycosides from <i>Alangium chinense</i> That Inhibit Spontaneous Calcium Oscillations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.04 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507974 | TETRODOTOXIN | 3.0 | 1 | 8.31 |
| CHEMBL5176726 | — | — | 1 | 6.01 |
| CHEMBL5174024 | — | — | 1 | 5.72 |
| CHEMBL5188378 | — | — | 1 | 5.69 |
| CHEMBL5175542 | — | — | 1 | 5.59 |
| CHEMBL5178699 | — | — | 1 | 5.51 |
| CHEMBL5209529 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507974 | TETRODOTOXIN | IC50 | = | 4.93 | nM | 8.31 |
| CHEMBL5176726 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5174024 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5188378 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL5175542 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5178699 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL5209529 | — | IC50 | = | 3450.0 | nM | 5.46 |