Assay Detail
Binding
CHEMBL5133657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE by Ellman's method
65
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 6.06 | 7.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 2 | 7.83 |
| CHEMBL5190924 | — | — | 1 | 7.16 |
| CHEMBL5185533 | — | — | 2 | 7.16 |
| CHEMBL5179810 | — | — | 1 | 7.07 |
| CHEMBL5190563 | — | — | 2 | 7.07 |
| CHEMBL5181578 | — | — | 2 | 6.80 |
| CHEMBL5176418 | — | — | 2 | 6.70 |
| CHEMBL5178755 | — | — | 1 | 6.60 |
| CHEMBL5196896 | — | — | 2 | 6.60 |
| CHEMBL5206986 | — | — | 1 | 6.55 |
| CHEMBL5171343 | — | — | 1 | 6.48 |
| CHEMBL5206933 | — | — | 2 | 6.46 |
| CHEMBL5203832 | — | — | 2 | 6.43 |
| CHEMBL5204683 | — | — | 1 | 6.43 |
| CHEMBL5173121 | — | — | 2 | 6.34 |
| CHEMBL5207035 | — | — | 2 | 6.24 |
| CHEMBL5186582 | — | — | 1 | 6.20 |
| CHEMBL5181896 | — | — | 1 | 6.17 |
| CHEMBL5175264 | — | — | 1 | 6.13 |
| CHEMBL5202368 | — | — | 1 | 6.06 |
| CHEMBL5190793 | — | — | 1 | 6.05 |
| CHEMBL5196610 | — | — | 1 | 6.04 |
| CHEMBL5186646 | — | — | 1 | 6.03 |
| CHEMBL5188135 | — | — | 2 | 6.00 |
| CHEMBL5204131 | — | — | 1 | 5.99 |
| CHEMBL5179648 | — | — | 2 | 5.94 |
| CHEMBL5208706 | — | — | 1 | 5.93 |
| CHEMBL5200573 | — | — | 2 | 5.92 |
| CHEMBL5194681 | — | — | 1 | 5.84 |
| CHEMBL5187201 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 14.79 | nM | 7.83 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5185533 | — | IC50 | = | 69.18 | nM | 7.16 |
| CHEMBL5190924 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5179810 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5190563 | — | IC50 | = | 85.11 | nM | 7.07 |
| CHEMBL5181578 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5181578 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5176418 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5176418 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5178755 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5196896 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5196896 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5206986 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5171343 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5206933 | — | IC50 | = | 346.74 | nM | 6.46 |
| CHEMBL5206933 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5203832 | — | IC50 | = | 371.54 | nM | 6.43 |
| CHEMBL5204683 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5173121 | — | IC50 | = | 457.09 | nM | 6.34 |
| CHEMBL5173121 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5207035 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5207035 | — | IC50 | = | 575.44 | nM | 6.24 |
| CHEMBL5185533 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5186582 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5181896 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5175264 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5203832 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5202368 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5190793 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5196610 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5186646 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5188135 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5188135 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5204131 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5190563 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5179648 | — | IC50 | = | 1148.15 | nM | 5.94 |
| CHEMBL5179648 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5208706 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL5200573 | — | IC50 | = | 1202.26 | nM | 5.92 |
| CHEMBL5200573 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL5194681 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL5201026 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5187201 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL5173447 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL5187296 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5182921 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL5171352 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5181784 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL5171981 | — | IC50 | = | 2270.0 | nM | 5.64 |