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Assay Detail

CHEMBL5133720

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antischistosomal activity against Schistosoma mansoni Liberian adult worms assessed as reduction in worm viability measured after 72 hrs by microscopy
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Schistosoma mansoni
Confidence 1 — Organism
Curated By Autocuration

Target

Schistosoma mansoni (CHEMBL612893)
Type ORGANISM
Organism Schistosoma mansoni

Publication

Antischistosomal tetrahydro-γ-carboline sulfonamides.
Ren R, Wang X, Leas DA, Häberli C, Cal M, Dong Y, Kaiser M, Keiser J, Vennerstrom JL.
Bioorg Med Chem Lett (2022) 59 : 128546 -128546
PubMed 35031451 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.11 7.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL976 PRAZIQUANTEL 4.0 1 7.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL976 PRAZIQUANTEL IC50 = 77.0 nM 7.11