Assay Detail
Binding
CHEMBL5133737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FLT3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a benzimidazole-based dual FLT3/TrKA inhibitor targeting acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.03 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1738757 | REBASTINIB | 2.0 | 1 | 8.70 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 7.90 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1738757 | REBASTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 32.6 | nM | 7.49 |