Assay Detail
Functional
CHEMBL5133804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CD69 expression on CD19 positive B cells in anti-IgD stimulated human whole blood
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Cell Type | CD19 positive B cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.35 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188786 | — | — | 1 | 7.52 |
| CHEMBL4483575 | REMIBRUTINIB | 3.0 | 1 | 7.44 |
| CHEMBL5186635 | — | — | 1 | 6.89 |
| CHEMBL5197765 | — | — | 1 | 6.89 |
| CHEMBL5197926 | — | — | 1 | 6.80 |
| CHEMBL5188750 | — | — | 1 | 6.52 |
| CHEMBL5173641 | — | — | 1 | 6.52 |
| CHEMBL5170448 | — | — | 1 | 6.44 |
| CHEMBL5180944 | — | — | 1 | 6.20 |
| CHEMBL5172575 | — | — | 1 | 6.05 |
| CHEMBL5189311 | — | — | 1 | 6.04 |
| CHEMBL5182804 | — | — | 1 | 5.97 |
| CHEMBL5204339 | — | — | 1 | 5.97 |
| CHEMBL5179299 | — | — | 1 | 5.70 |
| CHEMBL5207401 | — | — | 1 | 5.36 |
| CHEMBL5207026 | — | — | 1 | 5.33 |
| CHEMBL5207396 | — | — | 1 | - |
| CHEMBL5188545 | — | — | 1 | - |
| CHEMBL5206619 | — | — | 1 | - |
| CHEMBL5191642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188786 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4483575 | REMIBRUTINIB | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5186635 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5197765 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5197926 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5188750 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5173641 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5170448 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5180944 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5172575 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5189311 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5182804 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5204339 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5179299 | — | IC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL5207401 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL5207026 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5207396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5188545 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5206619 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5191642 | — | IC50 | > | 10000.0 | nM | - |