Assay Detail
Binding
CHEMBL5133908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation of Gal4-fused human PPARgamma expressed in CHO cells co expressing pG5-Luc reporter
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.91 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180073 | — | — | 1 | 6.27 |
| CHEMBL5183133 | — | — | 1 | 6.17 |
| CHEMBL5178616 | — | — | 1 | 6.01 |
| CHEMBL5180328 | — | — | 1 | 6.01 |
| CHEMBL5193666 | — | — | 1 | 5.97 |
| CHEMBL5185420 | — | — | 1 | 5.59 |
| CHEMBL38943 | GW501516 | 2.0 | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180073 | — | EC50 | = | 542.0 | nM | 6.27 |
| CHEMBL5183133 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5178616 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5180328 | — | EC50 | = | 987.0 | nM | 6.01 |
| CHEMBL5193666 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5185420 | — | EC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL38943 | GW501516 | EC50 | = | 4400.0 | nM | 5.36 |