Assay Detail
Binding
CHEMBL5134020
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Activation of human RNase L using [CY5]-r(C11-UUC7)- [BHQ2] as substrate assessed as cleavage of fluorescent substrate by measuring increase in fluorescence incubated for 30 mins by FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5'-Phosphonate modified oligoadenylates as potent activators of human RNase L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.53 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414948 | — | — | 1 | 7.82 |
| CHEMBL5195984 | — | — | 1 | 7.72 |
| CHEMBL5204273 | — | — | 1 | 7.68 |
| CHEMBL5175807 | — | — | 1 | 7.47 |
| CHEMBL5198253 | — | — | 1 | 7.45 |
| CHEMBL5192451 | — | — | 1 | 7.34 |
| CHEMBL5209422 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414948 | — | EC50 | = | 15.3 | nM | 7.82 |
| CHEMBL5195984 | — | EC50 | = | 18.9 | nM | 7.72 |
| CHEMBL5204273 | — | EC50 | = | 20.9 | nM | 7.68 |
| CHEMBL5175807 | — | EC50 | = | 33.8 | nM | 7.47 |
| CHEMBL5198253 | — | EC50 | = | 35.7 | nM | 7.45 |
| CHEMBL5192451 | — | EC50 | = | 46.1 | nM | 7.34 |
| CHEMBL5209422 | — | EC50 | = | 55.2 | nM | 7.26 |