Assay Detail
Functional
CHEMBL5134916
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GPR39 receptor expressed in CHO cells assessed as increase in ca2+ flux
20
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.28 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207240 | — | — | 1 | 8.52 |
| CHEMBL3342358 | — | — | 1 | 7.82 |
| CHEMBL5182651 | — | — | 1 | 7.82 |
| CHEMBL5195894 | — | — | 1 | 7.80 |
| CHEMBL5192920 | — | — | 1 | 7.77 |
| CHEMBL5177479 | — | — | 2 | 7.77 |
| CHEMBL5180126 | — | — | 1 | 7.20 |
| CHEMBL5181574 | — | — | 1 | 7.11 |
| CHEMBL5181167 | — | — | 2 | 7.10 |
| CHEMBL5200611 | — | — | 1 | 6.32 |
| CHEMBL3092413 | — | — | 1 | 5.20 |
| CHEMBL5195424 | — | — | 1 | - |
| CHEMBL5174704 | — | — | 1 | - |
| CHEMBL5170821 | — | — | 2 | - |
| CHEMBL5193472 | — | — | 1 | - |
| CHEMBL5203229 | — | — | 1 | - |
| CHEMBL5180932 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207240 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3342358 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5182651 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5195894 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5192920 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5177479 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5177479 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5180126 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5181574 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5181167 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5181167 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5200611 | — | EC50 | = | 481.0 | nM | 6.32 |
| CHEMBL3092413 | — | EC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL5195424 | — | EC50 | > | 31600.0 | nM | - |
| CHEMBL5174704 | — | EC50 | > | 31600.0 | nM | - |
| CHEMBL5170821 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5170821 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5193472 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5203229 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5180932 | — | EC50 | > | 50000.0 | nM | - |