Assay Detail
Functional
CHEMBL5135075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against intracellular Leishmania infantum MHOM/MA(BE)/67 amastigotes infected in Swiss mouse peritoneal macrophages assessed as parasite growth inhibition incubated for 5 days by giemsa staining based microscopic analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N<sup>6</sup>-modification of 7-Deazapurine nucleoside analogues as Anti-Trypanosoma cruzi and anti-Leishmania agents: Structure-activity relationship exploration and In vivo evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 5.55 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | — | 1 | 6.89 |
| CHEMBL5200044 | — | — | 1 | 6.44 |
| CHEMBL3126898 | — | — | 1 | 6.31 |
| CHEMBL5195584 | — | — | 1 | 6.29 |
| CHEMBL5182317 | — | — | 1 | 5.96 |
| CHEMBL262874 | — | — | 1 | 5.96 |
| CHEMBL98424 | — | — | 1 | 5.86 |
| CHEMBL5174504 | — | — | 1 | 5.58 |
| CHEMBL5199723 | — | — | 1 | 5.42 |
| CHEMBL5205233 | — | — | 1 | 5.22 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.08 |
| CHEMBL5207202 | — | — | 1 | 4.71 |
| CHEMBL5174803 | — | — | 1 | 4.67 |
| CHEMBL5203151 | — | — | 1 | 4.46 |
| CHEMBL4436060 | — | — | 1 | 4.41 |
| CHEMBL5170491 | — | — | 1 | - |
| CHEMBL5180850 | — | — | 1 | - |
| CHEMBL3126906 | — | — | 1 | - |
| CHEMBL5191825 | — | — | 1 | - |
| CHEMBL5196805 | — | — | 1 | - |
| CHEMBL5169613 | — | — | 1 | - |
| CHEMBL5194808 | — | — | 1 | - |
| CHEMBL5207667 | — | — | 1 | - |
| CHEMBL4782563 | — | — | 1 | - |
| CHEMBL5189880 | — | — | 1 | - |
| CHEMBL5184615 | — | — | 1 | - |
| CHEMBL5209135 | — | — | 1 | - |
| CHEMBL5178932 | — | — | 1 | - |
| CHEMBL5187821 | — | — | 1 | - |
| CHEMBL2023963 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267099 | TUBERCIDIN | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5200044 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3126898 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5195584 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5182317 | — | EC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL262874 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL98424 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5174504 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL5199723 | — | EC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5205233 | — | EC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5207202 | — | EC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL5174803 | — | EC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL5203151 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL4436060 | — | EC50 | = | 38900.0 | nM | 4.41 |
| CHEMBL5170491 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5180850 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL3126906 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5191825 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5196805 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5169613 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5194808 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5207667 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4782563 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5189880 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5184615 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5209135 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5178932 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL5187821 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL2023963 | — | EC50 | > | 64000.0 | nM | - |