Assay Detail
Functional
CHEMBL5135114
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Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth measured after 68 hrs by MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Harringtonine Ester Derivatives with Enhanced Antiproliferative Activities against HL-60 and HeLa Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.12 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189850 | — | — | 1 | 6.40 |
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | 4.0 | 1 | 5.77 |
| CHEMBL5200911 | — | — | 1 | 5.72 |
| CHEMBL5182410 | — | — | 1 | 5.70 |
| CHEMBL433257 | HARRINGTONINE | — | 1 | 5.40 |
| CHEMBL5181962 | — | — | 1 | 5.22 |
| CHEMBL5184508 | — | — | 1 | 4.97 |
| CHEMBL5205099 | — | — | 1 | 4.80 |
| CHEMBL5194384 | — | — | 1 | 4.62 |
| CHEMBL5174225 | — | — | 1 | 4.62 |
| CHEMBL5182991 | — | — | 1 | 4.22 |
| CHEMBL5191809 | — | — | 1 | 4.01 |
| CHEMBL4174530 | — | — | 1 | - |
| CHEMBL5203961 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189850 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5200911 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5182410 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL433257 | HARRINGTONINE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5181962 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5184508 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL5205099 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL5194384 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL5174225 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL5182991 | — | IC50 | = | 60600.0 | nM | 4.22 |
| CHEMBL5191809 | — | IC50 | = | 97900.0 | nM | 4.01 |
| CHEMBL4174530 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5203961 | — | IC50 | > | 100000.0 | nM | - |