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Assay Detail

CHEMBL5135398

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine liver beta-glucosidase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design, synthesis and glycosidase inhibition of C-4 branched LAB and DAB derivatives.
Wang JZ, Cheng B, Kato A, Kise M, Shimadate Y, Jia YM, Li YX, Fleet GWJ, Yu CY.
Eur J Med Chem (2022) 233 : 114230 -114230
PubMed 35255314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 5 4.15 4.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5189075 1 4.15
CHEMBL2177689 1 -
CHEMBL5198563 1 -
CHEMBL5192700 1 -
CHEMBL80254 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5189075 IC50 = 71000.0 nM 4.15
CHEMBL2177689 IC50 = 183000.0 nM -
CHEMBL5198563 IC50 = 226000.0 nM -
CHEMBL5192700 IC50 = 430000.0 nM -
CHEMBL80254 IC50 = 638000.0 nM -