Assay Detail
Toxicity
CHEMBL5135461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG potassium channel expressed in CHO cells at -80 mV holding potential by whole cell patch clamp assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Improving the treatment of Parkinson's disease: Structure-based development of novel 5-HT<sub>2A</sub> receptor antagonists/inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.93 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2111101 | PIMAVANSERIN | 4.0 | 1 | 6.39 |
| CHEMBL5205903 | — | — | 1 | 5.96 |
| CHEMBL5197899 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2111101 | PIMAVANSERIN | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5205903 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5197899 | — | IC50 | = | 3610.0 | nM | 5.44 |