Assay Detail
Binding
CHEMBL5135586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC1 using ZMAL (Z-(Ac)Lys-AMC as substrate incubated for 20 mins and measured by homogenous fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.42 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.03 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 5.72 |
| CHEMBL5173958 | — | — | 1 | 5.52 |
| CHEMBL5188463 | — | — | 1 | 5.05 |
| CHEMBL5184156 | — | — | 1 | 4.80 |
| CHEMBL5201544 | — | — | 1 | - |
| CHEMBL5188225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL5173958 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5188463 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5184156 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5201544 | — | IC50 | - | — | - | |
| CHEMBL5188225 | — | IC50 | - | — | - |