Assay Detail
Functional
CHEMBL5135607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African Green monkey Vero cells assessed as inhibition of viral cytopathic effect measured after 72 hrs by inverted microscopic method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero E6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.03 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476635 | — | — | 1 | 7.24 |
| CHEMBL2088014 | — | — | 1 | 6.42 |
| CHEMBL2088011 | — | — | 1 | 6.41 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.40 |
| CHEMBL589733 | — | — | 1 | 6.31 |
| CHEMBL2088010 | — | — | 1 | 5.96 |
| CHEMBL2088009 | — | — | 1 | 5.89 |
| CHEMBL2179170 | — | — | 1 | 5.82 |
| CHEMBL1491305 | — | — | 1 | 5.78 |
| CHEMBL449782 | CEPHARANTHINE | 2.0 | 1 | 5.55 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 5.48 |
| CHEMBL1892375 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476635 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2088014 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2088011 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL589733 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL2088010 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL2088009 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL2179170 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL1491305 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL449782 | CEPHARANTHINE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1892375 | — | IC50 | = | 8590.0 | nM | 5.07 |