Assay Detail

CHEMBL5135688

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Binding

Inhibition of bacterial beta-lactamase KPC-2 using nitrocefin as substrate incubated for 10 mins and measured every 10 seconds for 10 mins

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Bacteria
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Structure and Mechanism-Guided Design of Dual Serine/Metallo-Carbapenemase Inhibitors.

Chen C, Oelschlaeger P, Wang D, Xu H, Wang Q, Wang C, Zhao A, Yang KW.
J Med Chem (2022) 65 : 5954 -5974
PubMed 35420040 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.54	8.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4633785	XERUBORBACTAM	1.0	1	8.54

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4633785	XERUBORBACTAM	IC50	=	2.9	nM	8.54