Assay Detail
Binding
CHEMBL5135849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to 5HT6 receptor (unknown origin) assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Highly Potent Serotonin 5-HT<sub>2</sub> Receptor Agonists Inspired by Heteroyohimbine Natural Products.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.08 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207529 | — | — | 1 | 7.54 |
| CHEMBL5170784 | — | — | 1 | 7.32 |
| CHEMBL5204071 | — | — | 1 | 7.16 |
| CHEMBL5182943 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207529 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL5170784 | — | Ki | = | 47.7 | nM | 7.32 |
| CHEMBL5204071 | — | Ki | = | 68.8 | nM | 7.16 |
| CHEMBL5182943 | — | Ki | = | 530.0 | nM | 6.28 |