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Assay Detail

CHEMBL5135901

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against SARS-CoV-2 infected in eGFP expressing African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect measured after 4 days post infection by laser scanning microscopic analysis
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Severe acute respiratory syndrome coronavirus 2
Cell Type Vero E6
Confidence 1 — Organism
Curated By Autocuration

Target

SARS-CoV-2 (CHEMBL4303835)
Type ORGANISM
Organism Severe acute respiratory syndrome coronavirus 2

Publication

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.
Nizi MG, Persoons L, Corona A, Felicetti T, Cernicchi G, Massari S, Manfroni G, Vangeel L, Barreca ML, Esposito F, Jochmans D, Milia J, Cecchetti V, Schols D, Neyts J, Tramontano E, Sabatini S, De Jonghe S, Tabarrini O.
ACS Med Chem Lett (2022) 13 : 855 -864
PubMed 35571875 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 42 5.16 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2016757 GS-441524 1.0 1 6.16
CHEMBL4164426 1 5.58
CHEMBL5181347 1 5.57
CHEMBL5185967 1 5.34
CHEMBL4175717 1 5.29
CHEMBL5209332 1 5.23
CHEMBL1651180 1 5.19
CHEMBL4171241 1 5.15
CHEMBL5173495 1 5.10
CHEMBL5176275 1 5.08
CHEMBL4175014 1 5.06
CHEMBL4164881 1 5.04
CHEMBL5199587 1 5.02
CHEMBL5202049 1 5.00
CHEMBL76 CHLOROQUINE 4.0 1 4.96
CHEMBL5202059 1 4.95
CHEMBL2385690 1 4.92
CHEMBL4168943 1 4.89
CHEMBL5200563 1 4.45
CHEMBL5178596 1 -
CHEMBL5203879 1 -
CHEMBL5207579 1 -
CHEMBL5179141 1 -
CHEMBL5205075 1 -
CHEMBL5204334 1 -
CHEMBL5189638 1 -
CHEMBL1651165 1 -
CHEMBL5182758 1 -
CHEMBL3039902 1 -
CHEMBL4170066 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2016757 GS-441524 EC50 = 700.0 nM 6.16
CHEMBL4164426 EC50 = 2600.0 nM 5.58
CHEMBL5181347 EC50 = 2700.0 nM 5.57
CHEMBL5185967 EC50 = 4600.0 nM 5.34
CHEMBL4175717 EC50 = 5100.0 nM 5.29
CHEMBL5209332 EC50 = 5900.0 nM 5.23
CHEMBL1651180 EC50 = 6500.0 nM 5.19
CHEMBL4171241 EC50 = 7100.0 nM 5.15
CHEMBL5173495 EC50 = 7900.0 nM 5.10
CHEMBL5176275 EC50 = 8300.0 nM 5.08
CHEMBL4175014 EC50 = 8800.0 nM 5.06
CHEMBL4164881 EC50 = 9100.0 nM 5.04
CHEMBL5199587 EC50 = 9600.0 nM 5.02
CHEMBL5202049 EC50 = 10000.0 nM 5.00
CHEMBL76 CHLOROQUINE EC50 = 10900.0 nM 4.96
CHEMBL5202059 EC50 = 11300.0 nM 4.95
CHEMBL2385690 EC50 = 11900.0 nM 4.92
CHEMBL4168943 EC50 = 13000.0 nM 4.89
CHEMBL5200563 EC50 = 35900.0 nM 4.45
CHEMBL2385671 EC50 > 100000.0 nM -
CHEMBL4169246 EC50 > 100000.0 nM -
CHEMBL4173506 EC50 > 100000.0 nM -
CHEMBL4174957 EC50 > 40000.0 nM -
CHEMBL4165958 EC50 > 100000.0 nM -
CHEMBL5207812 EC50 > 100000.0 nM -
CHEMBL4163342 EC50 > 100000.0 nM -
CHEMBL5178908 EC50 > 100000.0 nM -
CHEMBL2385672 EC50 > 100000.0 nM -
CHEMBL3039955 EC50 > 100000.0 nM -
CHEMBL2385673 EC50 > 100000.0 nM -
CHEMBL5195977 EC50 > 100000.0 nM -
CHEMBL4170066 EC50 > 100000.0 nM -
CHEMBL3039902 EC50 > 100000.0 nM -
CHEMBL5182758 EC50 > 100000.0 nM -
CHEMBL1651165 EC50 > 100000.0 nM -
CHEMBL5189638 EC50 > 100000.0 nM -
CHEMBL5204334 EC50 > 100000.0 nM -
CHEMBL5205075 EC50 > 100000.0 nM -
CHEMBL5179141 EC50 > 100000.0 nM -
CHEMBL5207579 EC50 > 100000.0 nM -
CHEMBL5203879 EC50 > 100000.0 nM -
CHEMBL5178596 EC50 > 100000.0 nM -