Assay Detail
Functional
CHEMBL5136407
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human PC-3 cells assessed as cell viability incubated for 72 to 96 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a High Affinity Adenosine A<sub>1</sub>/A<sub>3</sub> Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-<i>d</i>]pyridazine Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.28 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197567 | — | — | 1 | 5.28 |
| CHEMBL5185411 | — | — | 1 | - |
| CHEMBL5195631 | — | — | 1 | - |
| CHEMBL5175347 | — | — | 1 | - |
| CHEMBL5203865 | — | — | 1 | - |
| CHEMBL5183118 | — | — | 1 | - |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | - |
| CHEMBL88147 | — | — | 1 | - |
| CHEMBL464859 | NECA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197567 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5185411 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5195631 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5175347 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5203865 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5183118 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | IC50 | > | 10000.0 | nM | - |
| CHEMBL88147 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL464859 | NECA | IC50 | > | 10000.0 | nM | - |