Assay Detail
Binding
CHEMBL5136477
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Inhibition of rat VMAT2 transfected in HEK cells using FFN206 as fluorescent substrate preincubated for 1 hr followed by substrate addition and measured after 30 mins by fluorescence plate reader assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Synaptic vesicular amine transporter (CHEMBL4828) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Ibogaine and Their Analogs as Therapeutics for Neurological and Psychiatric Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.12 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176306 | — | — | 1 | 7.16 |
| CHEMBL5207655 | — | — | 1 | 7.10 |
| CHEMBL5207764 | — | — | 1 | 6.77 |
| CHEMBL5188930 | — | — | 1 | 6.36 |
| CHEMBL5202868 | — | — | 1 | 6.24 |
| CHEMBL5171433 | — | — | 1 | 6.13 |
| CHEMBL5180373 | — | — | 1 | 6.12 |
| CHEMBL5201219 | — | — | 1 | 5.82 |
| CHEMBL5184088 | — | — | 1 | 5.52 |
| CHEMBL5175119 | — | — | 1 | 5.48 |
| CHEMBL1215855 | — | — | 1 | 5.40 |
| CHEMBL5188726 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176306 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5207655 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5207764 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5188930 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5202868 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5171433 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5180373 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5201219 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5184088 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5175119 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1215855 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5188726 | — | IC50 | = | 4900.0 | nM | 5.31 |