Assay Detail
Functional
CHEMBL5136570
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Inhibition of LPS/MDP-stimulated TNFalpha production in C57BL/6J mouse BMDM cells by ELISA relative to control
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BMDM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.52 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177284 | — | — | 1 | 9.52 |
| CHEMBL5195615 | — | — | 1 | 8.77 |
| CHEMBL5177727 | — | — | 1 | 8.64 |
| CHEMBL5174069 | — | — | 1 | 8.42 |
| CHEMBL5206121 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177284 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5195615 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5177727 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5174069 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5206121 | — | IC50 | = | 57.7 | nM | 7.24 |