Assay Detail
Binding
CHEMBL5136571
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human RIPK2 incubated for 120 mins in presence of [gamma33P]ATP by scintillation counting based radiometry assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 2 (CHEMBL5014) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 8.17 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5187454 | — | — | 1 | 9.10 |
| CHEMBL5195615 | — | — | 1 | 8.80 |
| CHEMBL5171377 | — | — | 1 | 8.62 |
| CHEMBL5197634 | — | — | 1 | 8.52 |
| CHEMBL5205764 | — | — | 1 | 8.41 |
| CHEMBL5205532 | — | — | 1 | 8.40 |
| CHEMBL5174069 | — | — | 1 | 8.38 |
| CHEMBL5171074 | — | — | 1 | 8.28 |
| CHEMBL5169942 | — | — | 1 | 8.23 |
| CHEMBL5187179 | — | — | 1 | 8.22 |
| CHEMBL5184606 | — | — | 1 | 8.20 |
| CHEMBL5180091 | — | — | 1 | 8.19 |
| CHEMBL5175396 | — | — | 1 | 8.17 |
| CHEMBL5191232 | — | — | 1 | 8.10 |
| CHEMBL5207306 | — | — | 1 | 8.05 |
| CHEMBL5174176 | — | — | 1 | 7.97 |
| CHEMBL5191796 | — | — | 1 | 7.97 |
| CHEMBL5189173 | — | — | 1 | 7.93 |
| CHEMBL5172982 | — | — | 1 | 7.81 |
| CHEMBL5204246 | — | — | 1 | 7.78 |
| CHEMBL5170201 | — | — | 1 | 7.73 |
| CHEMBL5185309 | — | — | 1 | 7.68 |
| CHEMBL5206121 | — | — | 1 | 7.47 |
| CHEMBL5169652 | — | — | 1 | - |
| CHEMBL5184501 | — | — | 1 | - |
| CHEMBL5195124 | — | — | 1 | - |
| CHEMBL5206318 | — | — | 1 | - |
| CHEMBL5201038 | — | — | 1 | - |
| CHEMBL5181298 | — | — | 1 | - |
| CHEMBL5202296 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5187454 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5195615 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL5171377 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5197634 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5205764 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5205532 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5174069 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5171074 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL5169942 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL5187179 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5184606 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL5180091 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL5175396 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5191232 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5207306 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5174176 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL5191796 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL5189173 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL5172982 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL5204246 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL5170201 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL5185309 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL5206121 | — | IC50 | = | 33.8 | nM | 7.47 |
| CHEMBL5169652 | — | IC50 | - | — | - | |
| CHEMBL5184501 | — | IC50 | - | — | - | |
| CHEMBL5195124 | — | IC50 | - | — | - | |
| CHEMBL5206318 | — | IC50 | - | — | - | |
| CHEMBL5201038 | — | IC50 | - | — | - | |
| CHEMBL5181298 | — | IC50 | - | — | - | |
| CHEMBL5202296 | — | IC50 | - | — | - | |
| CHEMBL5176553 | — | IC50 | - | — | - | |
| CHEMBL5191523 | — | IC50 | - | — | - | |
| CHEMBL5172451 | — | IC50 | - | — | - | |
| CHEMBL5174686 | — | IC50 | - | — | - |