Assay Detail
Binding
CHEMBL5136656
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Inhibition of MERS-CoV -Mpro using Ac-Abu-Tle-Leu-Gln-ACC as substrate incubated for 2 hrs by FRET based assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Middle East respiratory syndrome-related coronavirus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.42 | 7.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1821850 | — | — | 1 | 7.11 |
| CHEMBL5177782 | — | — | 1 | 7.10 |
| CHEMBL5199191 | — | — | 1 | 6.71 |
| CHEMBL5199531 | — | — | 1 | 6.65 |
| CHEMBL5188939 | — | — | 1 | 6.57 |
| CHEMBL5169323 | — | — | 1 | 6.52 |
| CHEMBL5207392 | — | — | 1 | 6.42 |
| CHEMBL5189565 | — | — | 1 | 6.31 |
| CHEMBL5204064 | — | — | 1 | 6.30 |
| CHEMBL5191017 | — | — | 1 | 6.28 |
| CHEMBL5204130 | — | — | 1 | 6.27 |
| CHEMBL5184362 | — | — | 1 | 6.21 |
| CHEMBL5173920 | — | — | 1 | 6.03 |
| CHEMBL5204452 | — | — | 1 | 5.95 |
| CHEMBL5207081 | — | — | 1 | 5.88 |
| CHEMBL5208709 | — | — | 1 | - |
| CHEMBL5192654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1821850 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5177782 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5199191 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL5199531 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL5188939 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL5169323 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL5207392 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL5189565 | — | IC50 | = | 486.0 | nM | 6.31 |
| CHEMBL5204064 | — | IC50 | = | 503.0 | nM | 6.30 |
| CHEMBL5191017 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL5204130 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL5184362 | — | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL5173920 | — | IC50 | = | 945.0 | nM | 6.03 |
| CHEMBL5204452 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5207081 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5208709 | — | IC50 | - | — | - | |
| CHEMBL5192654 | — | IC50 | - | — | - |