Assay Detail
Binding
CHEMBL5136673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged human CDK5/p25 expressed in Sf9 cells using histone H1 as substrate in presence of ATP and [gamma33-P] ATP by radioisotope filter binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3,5,7-Substituted Pyrazolo[4,3-<i>d</i>]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.23 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 7.89 |
| CHEMBL5169449 | — | — | 1 | 7.62 |
| CHEMBL5194202 | — | — | 1 | 7.41 |
| CHEMBL5182767 | — | — | 1 | 7.27 |
| CHEMBL5194833 | — | — | 1 | 6.90 |
| CHEMBL5187378 | — | — | 1 | 6.80 |
| CHEMBL5191136 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5169449 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5194202 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5182767 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL5194833 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5187378 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5191136 | — | IC50 | = | 179.0 | nM | 6.75 |