Assay Detail
Binding
CHEMBL5136917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at chick alpha7 nAChR expressed in stage VI oocytes assessed as inhibition of acetylcholine-induced current response pretreated for 30 secs followed by co-application with acetylcholine measured after 2 to 4 days in presence of atropine by voltage-clamp technique
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL5169123) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.96 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1257065 | STILONIUM IODIDE | 2.0 | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1257065 | STILONIUM IODIDE | IC50 | = | 109.0 | nM | 6.96 |