Assay Detail
Toxicity
CHEMBL5136953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by fluorescence polarization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Activity Relationship and <i>In Silico</i> Evaluation of <i>cis</i>- and <i>trans</i>-PCPA-Derived Inhibitors of LSD1 and LSD2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.79 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5206551 | — | — | 1 | 5.14 |
| CHEMBL5186086 | — | — | 1 | 5.11 |
| CHEMBL4285048 | — | — | 1 | 4.89 |
| CHEMBL5176392 | — | — | 1 | 4.82 |
| CHEMBL5204816 | — | — | 1 | 4.80 |
| CHEMBL5195724 | — | — | 1 | 4.75 |
| CHEMBL5206853 | — | — | 1 | 4.46 |
| CHEMBL5197683 | — | — | 1 | 4.36 |
| CHEMBL5201156 | — | — | 1 | - |
| CHEMBL5196815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5206551 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5186086 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4285048 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5176392 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5204816 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5195724 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5206853 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5197683 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL5201156 | — | IC50 | - | — | - | |
| CHEMBL5196815 | — | IC50 | - | — | - |