Assay Detail
Binding
CHEMBL5137273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human soluble NPP3 expressed in Sf9 insect cells using ATP as substrate measured after 4 hrs by capillary electrophoresis
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (CHEMBL5580) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 4.84 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2336905 | — | — | 1 | 7.27 |
| CHEMBL1160031 | REACTIVE BLUE 2 | — | 1 | 6.15 |
| CHEMBL1485038 | — | — | 1 | 5.96 |
| CHEMBL2336904 | — | — | 1 | 5.67 |
| CHEMBL5179873 | — | — | 1 | 5.48 |
| CHEMBL5177162 | — | — | 1 | 5.39 |
| CHEMBL5190049 | — | — | 1 | 5.29 |
| CHEMBL5186468 | — | — | 1 | 5.27 |
| CHEMBL5202320 | — | — | 1 | 5.25 |
| CHEMBL5204534 | — | — | 1 | 5.05 |
| CHEMBL2313213 | — | — | 1 | 4.99 |
| CHEMBL5192465 | — | — | 1 | 4.81 |
| CHEMBL5175797 | — | — | 1 | 4.71 |
| CHEMBL2336894 | — | — | 1 | 4.70 |
| CHEMBL5182554 | — | — | 1 | 4.70 |
| CHEMBL5208678 | — | — | 1 | 4.69 |
| CHEMBL5207807 | — | — | 1 | 4.62 |
| CHEMBL1561438 | — | — | 1 | 4.61 |
| CHEMBL5169839 | — | — | 1 | 4.59 |
| CHEMBL5198760 | — | — | 1 | 4.59 |
| CHEMBL197507 | — | — | 1 | 4.59 |
| CHEMBL5197692 | — | — | 1 | 4.59 |
| CHEMBL5176192 | — | — | 1 | 4.52 |
| CHEMBL5171120 | — | — | 1 | 4.52 |
| CHEMBL5201212 | — | — | 1 | 4.52 |
| CHEMBL5169491 | — | — | 1 | 4.51 |
| CHEMBL5191332 | — | — | 1 | 4.51 |
| CHEMBL5199666 | — | — | 1 | 4.46 |
| CHEMBL5205345 | — | — | 1 | 4.40 |
| CHEMBL1513693 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2336905 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL1160031 | REACTIVE BLUE 2 | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL1485038 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL2336904 | — | Ki | = | 2120.0 | nM | 5.67 |
| CHEMBL5179873 | — | Ki | = | 3340.0 | nM | 5.48 |
| CHEMBL5177162 | — | Ki | = | 4090.0 | nM | 5.39 |
| CHEMBL5190049 | — | Ki | = | 5090.0 | nM | 5.29 |
| CHEMBL5186468 | — | Ki | = | 5320.0 | nM | 5.27 |
| CHEMBL5202320 | — | Ki | = | 5570.0 | nM | 5.25 |
| CHEMBL5204534 | — | Ki | = | 8880.0 | nM | 5.05 |
| CHEMBL2313213 | — | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL5192465 | — | Ki | = | 15600.0 | nM | 4.81 |
| CHEMBL5175797 | — | Ki | = | 19700.0 | nM | 4.71 |
| CHEMBL2336894 | — | Ki | = | 20100.0 | nM | 4.70 |
| CHEMBL5182554 | — | Ki | = | 20100.0 | nM | 4.70 |
| CHEMBL5208678 | — | Ki | = | 20300.0 | nM | 4.69 |
| CHEMBL5207807 | — | Ki | = | 23700.0 | nM | 4.62 |
| CHEMBL1561438 | — | Ki | = | 24700.0 | nM | 4.61 |
| CHEMBL5169839 | — | Ki | = | 25700.0 | nM | 4.59 |
| CHEMBL5197692 | — | Ki | = | 25400.0 | nM | 4.59 |
| CHEMBL197507 | — | Ki | = | 25900.0 | nM | 4.59 |
| CHEMBL5198760 | — | Ki | = | 25400.0 | nM | 4.59 |
| CHEMBL5176192 | — | Ki | = | 30100.0 | nM | 4.52 |
| CHEMBL5171120 | — | Ki | = | 29900.0 | nM | 4.52 |
| CHEMBL5201212 | — | Ki | = | 30200.0 | nM | 4.52 |
| CHEMBL5169491 | — | Ki | = | 30600.0 | nM | 4.51 |
| CHEMBL5191332 | — | Ki | = | 30900.0 | nM | 4.51 |
| CHEMBL5199666 | — | Ki | = | 35100.0 | nM | 4.46 |
| CHEMBL5205345 | — | Ki | = | 40200.0 | nM | 4.40 |
| CHEMBL1513693 | — | Ki | = | 45200.0 | nM | 4.34 |
| CHEMBL5196274 | — | Ki | = | 49800.0 | nM | 4.30 |
| CHEMBL1556897 | — | Ki | = | 50700.0 | nM | 4.29 |
| CHEMBL5172284 | — | Ki | = | 50900.0 | nM | 4.29 |
| CHEMBL1475918 | — | Ki | = | 60700.0 | nM | 4.22 |
| CHEMBL5188097 | — | Ki | = | 74200.0 | nM | 4.13 |
| CHEMBL5185232 | — | Ki | = | 80700.0 | nM | 4.09 |