Assay Detail
Binding
CHEMBL5137282
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Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.67 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177162 | — | — | 1 | 7.14 |
| CHEMBL2336905 | — | — | 1 | 7.13 |
| CHEMBL5182554 | — | — | 1 | 7.13 |
| CHEMBL1561438 | — | — | 1 | 6.54 |
| CHEMBL1556897 | — | — | 1 | 6.03 |
| CHEMBL1485038 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177162 | — | Ki | = | 72.7 | nM | 7.14 |
| CHEMBL2336905 | — | Ki | = | 74.7 | nM | 7.13 |
| CHEMBL5182554 | — | Ki | = | 73.7 | nM | 7.13 |
| CHEMBL1561438 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL1556897 | — | Ki | = | 941.0 | nM | 6.03 |
| CHEMBL1485038 | — | Ki | = | 948.0 | nM | 6.02 |