Assay Detail
Functional
CHEMBL5137292
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Antiplatelet activity against ADP-induced human platelet in platelet rich plasma assessed as inhibition of platelet aggregation preincubated for 2 mins followed by ADP stimulation and measured for 5 mins by aggregometry
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of <i>N</i> <sup>6</sup> derivatives of 8-azapurine as novel antiplatelet agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.06 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623467 | — | — | 1 | 6.70 |
| CHEMBL3623479 | — | — | 1 | 6.40 |
| CHEMBL3623464 | — | — | 1 | 6.35 |
| CHEMBL5202516 | — | — | 1 | 6.24 |
| CHEMBL3623476 | — | — | 1 | 6.18 |
| CHEMBL3623466 | — | — | 1 | 6.17 |
| CHEMBL398435 | TICAGRELOR | 4.0 | 1 | 6.13 |
| CHEMBL3623468 | — | — | 1 | 6.11 |
| CHEMBL5170471 | — | — | 1 | 6.09 |
| CHEMBL3623471 | — | — | 1 | 5.89 |
| CHEMBL5207548 | — | — | 1 | 5.75 |
| CHEMBL5180982 | — | — | 1 | 5.50 |
| CHEMBL5173455 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623467 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3623479 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3623464 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5202516 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3623476 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3623466 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL398435 | TICAGRELOR | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3623468 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5170471 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL3623471 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5207548 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL5180982 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL5173455 | — | IC50 | = | 4890.0 | nM | 5.31 |