Assay Detail
Functional
CHEMBL5137305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P2Y12 receptor in human platelet assessed as reduction in ADP-induced VASP phosphorylation by flow cytometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of <i>N</i> <sup>6</sup> derivatives of 8-azapurine as novel antiplatelet agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.38 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398435 | TICAGRELOR | 4.0 | 1 | 7.41 |
| CHEMBL3623467 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398435 | TICAGRELOR | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3623467 | — | IC50 | = | 46.0 | nM | 7.34 |