Assay Detail
Binding
CHEMBL5137654
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Binding affinity to Mnk2 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 2 (CHEMBL4204) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Update on the Development of MNK Inhibitors as Therapeutic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.86 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439094 | — | — | 1 | 7.52 |
| CHEMBL5173114 | — | — | 1 | 7.40 |
| CHEMBL4466664 | — | — | 1 | 7.37 |
| CHEMBL4449736 | — | — | 1 | 7.09 |
| CHEMBL5174348 | — | — | 1 | 6.37 |
| CHEMBL4535537 | — | — | 1 | 6.36 |
| CHEMBL5180079 | — | — | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439094 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL5173114 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL4466664 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL4449736 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL5174348 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL4535537 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL5180079 | — | Ki | = | 1320.0 | nM | 5.88 |