Assay Detail
Binding
CHEMBL5137675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of eIF4E (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic translation initiation factor 4E (CHEMBL4848) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Update on the Development of MNK Inhibitors as Therapeutic Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.45 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175341 | — | — | 1 | 7.70 |
| CHEMBL5187414 | — | — | 1 | 7.70 |
| CHEMBL5184155 | — | — | 1 | 7.70 |
| CHEMBL5196084 | — | — | 1 | 7.60 |
| CHEMBL5195560 | — | — | 1 | 7.50 |
| CHEMBL5186068 | — | — | 1 | 7.40 |
| CHEMBL5183411 | — | — | 1 | 7.30 |
| CHEMBL5203734 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175341 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5187414 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5184155 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5196084 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL5195560 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL5186068 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5183411 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5203734 | — | IC50 | = | 199.53 | nM | 6.70 |