Assay Detail
Functional
CHEMBL5137947
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An Open Drug Discovery Competition: Experimental Validation of Predictive Models in a Series of Novel Antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.08 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137636 | — | — | 1 | 6.85 |
| CHEMBL3137631 | — | — | 1 | 6.72 |
| CHEMBL3137651 | — | — | 1 | 6.51 |
| CHEMBL4780715 | — | — | 1 | 6.43 |
| CHEMBL5189218 | — | — | 1 | 6.34 |
| CHEMBL5206139 | — | — | 1 | 5.91 |
| CHEMBL5174277 | — | — | 1 | 5.62 |
| CHEMBL3137620 | — | — | 1 | 5.30 |
| CHEMBL5182886 | — | — | 1 | 5.00 |
| CHEMBL3137627 | — | — | 1 | - |
| CHEMBL3137656 | — | — | 1 | - |
| CHEMBL3137567 | — | — | 1 | - |
| CHEMBL5182642 | — | — | 1 | - |
| CHEMBL5175723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137636 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3137631 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL3137651 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4780715 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5189218 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5206139 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5174277 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL3137620 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5182886 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3137627 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3137656 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3137567 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5182642 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5175723 | — | IC50 | > | 25000.0 | nM | - |