Assay Detail
Binding
CHEMBL5137950
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Inhibition of IDO1 (unknown origin)
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors and PROTAC-based degraders for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.89 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4747226 | — | — | 1 | 8.40 |
| CHEMBL4778760 | LY-3381916 | 1.0 | 1 | 8.15 |
| CHEMBL5201660 | — | — | 1 | 7.96 |
| CHEMBL5196354 | — | — | 1 | 7.94 |
| CHEMBL5173884 | — | — | 1 | 7.80 |
| CHEMBL4166767 | — | — | 1 | 7.75 |
| CHEMBL3989951 | NAVOXIMOD | 2.0 | 1 | 7.55 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.14 |
| CHEMBL4522927 | — | — | 1 | 7.07 |
| CHEMBL5173772 | — | — | 1 | 6.96 |
| CHEMBL4459180 | — | — | 1 | 6.96 |
| CHEMBL4086143 | PF-06840003 | 1.0 | 1 | 6.39 |
| CHEMBL3629570 | — | — | 1 | 6.33 |
| CHEMBL5202823 | — | — | 1 | 5.97 |
| CHEMBL4794771 | — | — | 1 | 5.52 |
| CHEMBL4443463 | — | — | 1 | 4.95 |
| CHEMBL14145 | — | — | 1 | 4.32 |
| CHEMBL5169351 | — | — | 1 | - |
| CHEMBL4176866 | — | — | 1 | - |
| CHEMBL4797341 | — | — | 1 | - |
| CHEMBL5180495 | — | — | 1 | - |
| CHEMBL5191227 | — | — | 1 | - |
| CHEMBL4786690 | — | — | 1 | - |
| CHEMBL5182238 | — | — | 1 | - |
| CHEMBL5203360 | — | — | 1 | - |
| CHEMBL5188753 | — | — | 1 | - |
| CHEMBL5176069 | — | — | 1 | - |
| CHEMBL5204616 | — | — | 1 | - |
| CHEMBL5187577 | — | — | 1 | - |
| CHEMBL5184643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4747226 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4778760 | LY-3381916 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5201660 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5196354 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5173884 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4166767 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3989951 | NAVOXIMOD | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4522927 | — | IC50 | = | 85.16 | nM | 7.07 |
| CHEMBL5173772 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4459180 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4086143 | PF-06840003 | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3629570 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL5202823 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4794771 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4443463 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL14145 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL5169351 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4176866 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL4797341 | — | IC50 | = | 1.57 | nM | - |
| CHEMBL5180495 | — | IC50 | < | 200.0 | nM | - |
| CHEMBL5191227 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL4786690 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL5182238 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5203360 | — | IC50 | > | 250.0 | nM | - |
| CHEMBL5188753 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5176069 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL5204616 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL5187577 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL5184643 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL5188903 | — | IC50 | < | 50.0 | nM | - |
| CHEMBL5191625 | — | IC50 | > | 50.0 | nM | - |