Assay Detail
Binding
CHEMBL5137958
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Inhibition of IDO1 in human HeLa cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors and PROTAC-based degraders for cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.17 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 8.13 |
| CHEMBL4443463 | — | — | 1 | 7.64 |
| CHEMBL4086143 | PF-06840003 | 1.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4443463 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4086143 | PF-06840003 | IC50 | = | 1800.0 | nM | 5.75 |