Assay Detail
Binding
CHEMBL5137975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PROTAC activity at VHL/LSD1/HDAC1/CoREST complex interaction (unknown origin) assessed as induction of HDAC1 degradation using Boc-(Ac)Lys-AMC as substrate incubated for 20 mins by fluorescence based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Medicinal chemistry updates of novel HDACs inhibitors (2020 to present).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.78 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5073757 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5073757 | — | IC50 | = | 16800.0 | nM | 4.78 |