Assay Detail
Binding
CHEMBL5138107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-fused full-length human DYRK1A (1 to 763 residues) expressed in baculovirus expression system using myelin basic protein peptide as substrate preincubated with substrate for 40 mins followed by compound addition measured after 1 hr in presence of ATP by TR-FRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (CHEMBL2292) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DYRK1A inhibitors for disease therapy: Current status and perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269538 | HARMINE | 1.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269538 | HARMINE | IC50 | = | 12.0 | nM | 7.92 |