Assay Detail
Functional
CHEMBL5138124
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Antiviral activity against HCV GT-1b Con1 in human Huh-5-2 cells carrying HCV subgenomic replicon assessed as drug resistance upto 100X EC50 and measured after 30 passages in presence of G418 by NGS analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-5-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 10.59 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023898 | DACLATASVIR | 4.0 | 1 | 10.59 |
| CHEMBL5181071 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023898 | DACLATASVIR | EC50 | = | 0.0257 | nM | 10.59 |
| CHEMBL5181071 | — | EC50 | = | 0.00266 | nM | - |