Assay Detail
Functional
CHEMBL5138136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Immunomodulatory activity in human MM cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Multiple myeloma cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A review on the treatment of multiple myeloma with small molecular agents in the past five years.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.99 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4170596 | — | — | 1 | 9.52 |
| CHEMBL3989927 | IBERDOMIDE | 3.0 | 1 | 7.89 |
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 1 | 7.46 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | 7.09 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4170596 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3989927 | IBERDOMIDE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL43452 | POMALIDOMIDE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL468 | THALIDOMIDE | IC50 | = | 194000.0 | nM | - |