Assay Detail

CHEMBL5138138

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Anticancer activity in human multiple myeloma cells

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Multiple myeloma cell
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

A review on the treatment of multiple myeloma with small molecular agents in the past five years.

Zhang Z, Liu X, Zhao L, Zhou Y, Shi J, Chen W, Li J.
Eur J Med Chem (2022) 229 : 114053 -114053
PubMed 34974338 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.47	7.57

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3137309	VENETOCLAX	4.0	1	7.57
CHEMBL3545185	SELINEXOR	4.0	1	7.36

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3137309	VENETOCLAX	IC50	=	26.67	nM	7.57
CHEMBL3545185	SELINEXOR	IC50	=	44.0	nM	7.36