Assay Detail
Binding
CHEMBL5138201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual-target inhibitors of poly (ADP-ribose) polymerase-1 for cancer therapy: Advances, challenges, and opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.64 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089840 | — | — | 1 | 7.00 |
| CHEMBL5205994 | — | — | 1 | 5.34 |
| CHEMBL1233300 | HYDROXYFASUDIL | — | 1 | 4.57 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089840 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5205994 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1233300 | HYDROXYFASUDIL | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 1260.0 | nM | - |