Assay Detail
Binding
CHEMBL5138230
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Inhibition of PRMT1 (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 1 (CHEMBL5524) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.75 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5197586 | — | — | 1 | 5.57 |
| CHEMBL5189462 | — | — | 1 | 5.14 |
| CHEMBL5179361 | — | — | 1 | 4.94 |
| CHEMBL5194544 | — | — | 1 | 4.93 |
| CHEMBL3245413 | — | — | 1 | 4.89 |
| CHEMBL5181815 | — | — | 1 | 4.75 |
| CHEMBL5195877 | — | — | 1 | 4.66 |
| CHEMBL25105 | HEXAMIDINE | 2.0 | 1 | 4.28 |
| CHEMBL61824 | — | — | 1 | 4.26 |
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5197586 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5189462 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5179361 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL5194544 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL3245413 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5181815 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL5195877 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL25105 | HEXAMIDINE | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL61824 | — | IC50 | = | 55400.0 | nM | 4.26 |
| CHEMBL55 | PENTAMIDINE | IC50 | = | 81000.0 | nM | 4.09 |