Assay Detail
Functional
CHEMBL5138236
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Inhibition of methylation of H3K79 in human MCF-10A cells by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.83 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188291 | — | — | 1 | 8.06 |
| CHEMBL4590355 | — | — | 1 | 7.80 |
| CHEMBL4534250 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188291 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4590355 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4534250 | — | IC50 | = | 23.0 | nM | 7.64 |