Assay Detail
Binding
CHEMBL5138337
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Inhibition of HDAC6 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.81 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356769 | TUBACIN | — | 1 | 8.40 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.05 |
| CHEMBL3426804 | — | — | 1 | 8.00 |
| CHEMBL4542499 | — | — | 1 | 7.96 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 7.82 |
| CHEMBL5193563 | — | — | 1 | 7.39 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356769 | TUBACIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3426804 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4542499 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5193563 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 96.0 | nM | 7.02 |