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Assay Detail

CHEMBL5138490

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Binding
Inhibition of urease (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

An overview on the synthetic urease inhibitors with structure-activity relationship and molecular docking.
Yang W, Feng Q, Peng Z, Wang G.
Eur J Med Chem (2022) 234 : 114273 -114273
PubMed 35305460 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.61 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5204038 1 6.96
CHEMBL4590676 1 6.82
CHEMBL5191414 1 6.30
CHEMBL4285715 1 6.15
CHEMBL5192542 1 6.06
CHEMBL5197816 1 5.92
CHEMBL5185317 1 5.74
CHEMBL4437765 1 5.41
CHEMBL3601761 1 5.07
CHEMBL268559 1 4.94
CHEMBL3600575 1 4.89
CHEMBL734 ACETOHYDROXAMIC ACID 4.0 1 4.54
CHEMBL430228 1 4.13
CHEMBL5182837 1 -
CHEMBL5185912 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5204038 IC50 = 110.0 nM 6.96
CHEMBL4590676 IC50 = 150.0 nM 6.82
CHEMBL5191414 IC50 = 500.0 nM 6.30
CHEMBL4285715 IC50 = 710.0 nM 6.15
CHEMBL5192542 IC50 = 870.0 nM 6.06
CHEMBL5197816 IC50 = 1207.0 nM 5.92
CHEMBL5185317 IC50 = 1820.0 nM 5.74
CHEMBL4437765 IC50 = 3900.0 nM 5.41
CHEMBL3601761 IC50 = 8530.0 nM 5.07
CHEMBL268559 IC50 = 11510.0 nM 4.94
CHEMBL3600575 IC50 = 13000.0 nM 4.89
CHEMBL734 ACETOHYDROXAMIC ACID IC50 = 29200.0 nM 4.54
CHEMBL430228 IC50 = 74300.0 nM 4.13
CHEMBL5182837 IC50 = 1.26 ug.mL-1 -
CHEMBL5185912 IC50 = 3.3 ug.mL-1 -