Assay Detail
Functional
CHEMBL5138571
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Ca9-22 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ca9-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.32 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9416 | ISOBUTYLSHIKONIN | — | 1 | 5.75 |
| CHEMBL9470 | SHIKONIN | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9416 | ISOBUTYLSHIKONIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 12810.0 | nM | 4.89 |