Assay Detail
Functional
CHEMBL5138680
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Anticancer activity against human K562 cells assessed as reduction in cell viability for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.25 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3327388 | — | — | 1 | 6.09 |
| CHEMBL28457 | ALKANNIN | — | 1 | 5.82 |
| CHEMBL5199683 | — | — | 1 | 5.43 |
| CHEMBL5189545 | — | — | 1 | 5.05 |
| CHEMBL5208936 | — | — | 1 | 4.73 |
| CHEMBL5174035 | — | — | 1 | 4.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3327388 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL28457 | ALKANNIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5199683 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL5189545 | — | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL5208936 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL5174035 | — | IC50 | = | 42500.0 | nM | 4.37 |