Assay Detail
Toxicity
CHEMBL5138683
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Cytotoxicity against human skin fibroblast cells incubated for 24 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | Fibroblast |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.75 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28457 | ALKANNIN | — | 1 | 5.75 |
| CHEMBL5199683 | — | — | 1 | - |
| CHEMBL5174035 | — | — | 1 | - |
| CHEMBL5208936 | — | — | 1 | - |
| CHEMBL5189545 | — | — | 1 | - |
| CHEMBL3327388 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28457 | ALKANNIN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5199683 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5174035 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5208936 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5189545 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3327388 | — | IC50 | > | 100000.0 | nM | - |