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Assay Detail

CHEMBL5138853

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and evaluation of a novel series of mono-indolylbenzoquinones derivatives for the potential treatment of breast cancer.
Jia J, Yin H, Chen C, Hu M, Zhong Q, Zheng S, Zhang W, Li H, Xu L, Wang G, He L.
Eur J Med Chem (2022) 237 : 114375 -114375
PubMed 35477142 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.10 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5178744 1 6.96
CHEMBL5179561 1 6.72
CHEMBL5207216 1 6.66
CHEMBL5189286 1 6.66
CHEMBL5170930 1 6.60
CHEMBL5190428 1 6.50
CHEMBL5189692 1 6.48
CHEMBL5185613 1 6.46
CHEMBL5184718 1 6.13
CHEMBL5174365 1 6.04
CHEMBL5204920 1 5.51
CHEMBL98 VORINOSTAT 4.0 1 5.34
CHEMBL5197849 1 5.30
CHEMBL5202847 1 5.20
CHEMBL5189964 1 5.01
CHEMBL5194750 1 -
CHEMBL5186535 1 -
CHEMBL487253 BENDAMUSTINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5178744 IC50 = 110.0 nM 6.96
CHEMBL5179561 IC50 = 190.0 nM 6.72
CHEMBL5207216 IC50 = 220.0 nM 6.66
CHEMBL5189286 IC50 = 220.0 nM 6.66
CHEMBL5170930 IC50 = 250.0 nM 6.60
CHEMBL5190428 IC50 = 320.0 nM 6.50
CHEMBL5189692 IC50 = 330.0 nM 6.48
CHEMBL5185613 IC50 = 350.0 nM 6.46
CHEMBL5184718 IC50 = 740.0 nM 6.13
CHEMBL5174365 IC50 = 920.0 nM 6.04
CHEMBL5204920 IC50 = 3110.0 nM 5.51
CHEMBL98 VORINOSTAT IC50 = 4520.0 nM 5.34
CHEMBL5197849 IC50 = 5050.0 nM 5.30
CHEMBL5202847 IC50 = 6300.0 nM 5.20
CHEMBL5189964 IC50 = 9730.0 nM 5.01
CHEMBL5194750 IC50 > 10000.0 nM -
CHEMBL5186535 IC50 > 10000.0 nM -
CHEMBL487253 BENDAMUSTINE IC50 > 20000.0 nM -