Assay Detail
Functional
CHEMBL5139772
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of quinazoline derivatives CZw-124 as a pan-TRK inhibitor with potent anticancer effects in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.30 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175892 | — | — | 1 | 5.77 |
| CHEMBL5206613 | — | — | 1 | 5.25 |
| CHEMBL5174615 | — | — | 1 | 5.14 |
| CHEMBL5193032 | — | — | 1 | 5.04 |
| CHEMBL4856292 | — | — | 1 | - |
| CHEMBL5184749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175892 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5206613 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5174615 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5193032 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4856292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5184749 | — | IC50 | > | 100000.0 | nM | - |